GLP-1(28-36)amide, a Long Ignored Peptide Revisited
نویسندگان
چکیده
منابع مشابه
GLP-1(28-36)amide, a Long Ignored Peptide Revisited
Glucagon-like peptide-1 (GLP-1), which has been extensively applied for treating type 2 diabetes mellitus (T2DM), is an incretin hormone that regulates glucose homeostasis. GLP-1(28-36)amide, a C-terminal nonapeptide (FIAWLVKGRamide) of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide has long been regarded as a metabolically ina...
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The receptor for GLP-1 [glucagon-like peptide-1-(7-36)-amide] is a member of the 'Family B' of GPCRs (G-protein-coupled receptors) comprising an extracellular N-terminal domain containing six conserved cysteine residues (the N-domain) and a core domain (or J-domain) comprising the seven transmembrane helices and interconnecting loop regions. According to the two-domain model for peptide binding...
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ژورنال
عنوان ژورنال: The Open Biochemistry Journal
سال: 2014
ISSN: 1874-091X
DOI: 10.2174/1874091x01408010107